UJI EFEKTIVITAS PENYEMBUHAN LUKA BAKAR SALEP EKSTRAK DAUN ADAM HAWA (Rhoeo discolor) PADA KELINCI JANTAN
DOI:
https://doi.org/10.64788/ar-rasyid.v1i5.64Keywords:
male rabbits, burn wounds, Rhoeo discolor, ointment.Abstract
Burn wounds are tissue damage caused by exposure to heat, chemicals, or electricity. Improper treatment of burn wounds can lead to complications such as infection, wound expansion, scarring, and even death. This study aimed to evaluate the effectiveness of Adam Hawa leaf extract ointment (Rhoeo discolor) in healing second-degree burns in male rabbits. The study employed an experimental method with treatment group design, consisting of a negative control group (vaseline), a positive control group (gentamicin ointment), and three treatment groups with extract concentrations of 10%, 15%, and 20%. Burns were induced thermally, and healing was observed over 14 days by measuring wound diameter every two days. The results showed that the 20% Adam Hawa leaf extract ointment was the most effective, with an average wound diameter of 0.83 cm, compared to 15% (1.04 cm), 10% (1.13 cm), the negative control (1.73 cm), and the positive control (0.80 cm). Statistical analysis showed significant differences between the groups, with a p-value of 0.000 < 0.05. Therefore, Adam Hawa leaf extract ointment is effective in accelerating burn wound healing, particularly at a concentration of 20%.
Downloads
References
1. Thedjakusuma FW, Nahusuly F, Arius Y. Perbandingan Tingkat Penyembuhan Luka Bakar Derajat II B ( Deep Dermal ) pada Fase Proliferasi yang Ditinjau dengan Pemberian Larutan Feracrylum 1 %, Tulle , dan Silver Sulfadiazine pada Mencit Mus musculus Abstrak. J Ked Mulawarman. 2022;9(3):122–31.
2. Laguliga JA, Erviani AE, Soekendarsi E. Test The Potency Of Jatropha Sap Jatropha Curcas Linn. On The Speed Of Wound Healing Burns On Therats Skin Rattus Norvegicus. Bioma J Biol Makassar [Internet]. 2021;6(2):74–83. Available from: http://journal. unhas.ac.id/index.php/bioma
3. Athandau DR, Laut MM, Utami T. Studi Literatur Uji Aktivitas Ekstrak Etanol Daun Anting-Anting (Acalypha indica Linn.) Terhadap Penyembuhan Luka Bakar Pada Hewan Coba. J Vet Nusant. 2023;6(2):350–63. Https://Doi.Org/10.35508/ Jvn. V 6i2.5663
4. Viana JE, Hidayat Z, Isminarti T, Astuti MD, Nakhil U. Gel “Madam” m Ekstrak Daun “Adam Hawa” (Rhoe discolor) sebagai Gel Antiinflamasi. Univ Res Colloq. 2017;1(9):161–70.
5. Klau MHC, Hesturini RJ. Pengaruh Pemberian Ekstrak Etanol Daun Dandang Gendis (Clinacanthus nutans (Burm F) Lindau) Terhadap Daya Analgetik Dan Gambaran Makroskopis Lambung Mencit. J Farm Sains Indones. 2021;4(1):6–12. Https://Doi.Org/10. 52216/ Jfsi. V4i1.59
6. Handayani D, Halimatushadyah E, Krismayadi K. Standarisasi Mutu Simplisia Rimpang Kunyit Dan Ekstrak Etanol Rimpang Kunyit (Curcuma longa Linn). Pharm Genius. 2023;2(1):43–59. Https://Doi.Org/ 10.56359/Pharmgen.V2i1.173
7. Pakiding DS. Penetapan Kadar Flavonoid Dan Uji Aktivitas Penghambat Enzim α-Amilase Ekstrak Etanol Dan Fraksi Akar Kersen (Muntingia calabura L.) Secara In Vitro. Duta Pharma J. 2022;2(2):67–79. Https:// Doi. Org/10.47701/Djp.V2i2.2280
8. Ulfa M, Kursia S, Sari MN. Uji Aktivitas Antibakteri Dari Ekstrak Etanol Daun Adam Hawa (Rhoeo discolor L.Her) Terhadap Propionibacterium Acnes, Staphylococcus Aureus dan Staphylococcus Epidermidis. Medfarm J Farm dan Kesehat. 2023;12(1):67–76. Https:// Doi.Org/ 10.48191/ Medfarm.V12i1.173
9. Rosidah I, Zainuddin Z, Agustini K, Bunga O, Pudjiastuti L. Standardisasi Ekstrak Etanol 70% Buah Labu Siam (Sechium edule (Jacq.) Sw.). Farmasains J Ilm Ilmu Kefarmasian. 2020;7(1):13–20. Https://Doi. Org/10.22236/Farmasains.V7i1.4175
10. A. Disi MZ, Rajih Hi Yusuf MF, Rahman I. Aktivitas Antioksidan dan Penentuan Kadar Total Flavonoid Fraksi Daging Buah Pala (Myristica fragrans houtt). J Syifa Sci Clin Res. 2024;6(3):287–300. Doi : https:// doi.org/10.37311/jsscr.v6i3.28740
11. Aini RN, Listyani TA, Raharjo D. Perbandingan Kadar Flavonoid Dan Aktivitas Antioksidan Ekstrak Etanol Dan Infusa Daun Rambutan (Nephelium lappaceum L.) Dengan Metode ABTS. J Ilm Wahana Pendidikan, Desember [Internet]. 2023;9(23):665–80. Available from: https://doi.org/ 10.5281/ zenodo. 10353550.
12. Rohama R, Zainuddin Z. Identifikasi Senyawa Metabolit Sekunder pada Ekstrak Daun Gayam (Inocarpus Fagifer Fosb) dengan Menggunakan KLT. J Surya Med. 2021;6(2):125–9. Https:// Doi.Org/ 10. 33084/ Jsm. V6i2.2129
13. Pujiati L, Sugiyanto S, Hasana AR. Uji Identifikasi Rhodamin B Pada Liptint Di Toko Kosmetik Kota X Menggunakan Metode Kromatografi Lapis Tipis. SENTRI J Ris Ilm. 2023;2(11):4554–64. Https://Doi. Org/ 10.55681/Sentri.V2i11.1765
14. Sari F, Hasanah F, Kristianingsih I, Sukmana A. Identifikasi Senyawa Metabolit Ekstrak Etanol Daun Beluntas (Pluche Indica) Secara Kualitatif Dengan Kromatografi Lapis Tipis. J Sint Penelit Sains, Terap dan Anal. 2022;3(1):1–7. Https://Doi.Org/ 10. 56399/ Jst.V3i1.25
15. Maryam F, Taebe B, Toding DP. Pengukuran Parameter Spesifik Dan Non Spesifik Ekstrak Etanol Daun Matoa (Pometia pinnata J.R & G.Forst). J Mandala Pharmacon Indones. 2020;6(01):1–12. Https://Doi.Org/10.35311/Jmpi.V6i01.39
16. Senduk TW, Montolalu LADY, Dotulong V. The rendement of boiled water extract of mature leaves of mangrove Sonneratia alba. J Perikan Dan Kelaut Trop. 2020;11(1):9. Https://Doi.Org/10.35800/ Jpkt. 11.1. 2020.28659
17. Badriyah L, Farihah D. Optimalisasi ekstraksi kulit bawang merah (Allium cepa L) menggunakan metode maserasi. J Sint Penelit Sains, Terap dan Anal. 2022;3(1):30–7. Https:// Doi.Org/10.56399/ Jst. V3i1. 32
18. Andira M, Shina I, Wardani TS, Siwi K. Uji Aktivitas Antibakteri Ekstrak , Fraksi Air, Fraksi Etil Asetat, Fraksi n- Heksan Daun Petai Cina (Leucaena leucocephala) Terhadap Bakteri Staphylococcus aureus ATCC 25923. Jurnal Riset Ilmu Farmasi dan Kesehatan, 2(6), 1-37. 2024;(6). Doi : https ://doi.org /10.61132/obat.v2i6.785
19. Tivani I, Amananti W, Rima Putri A. Uji AKtivitas Antibakteri Handwash Ekstak Daun Turi (Sesbania grandiflora L) Terhadap Staphylococus aureus. J Ilm Manutung. 2021;7(1):86–91.
20. Hasan H, Andy Suryadi AM, Bahri S, Widiastuti NL. Penentuan Kadar Flavonoid Daun Rumput Knop (Hyptis capitata Jacq.) Menggunakan Spektrofotometri UV-Vis. J Syifa Sci Clin Res. 2023;5(2):200–11. Https://Doi.Org/10.37311/Jsscr.V5i2.19371
21. Khasanah K, Rusmalina S, Loso L, Meilisa S, Hadi ND. Analisis mutu fisik, mikrobiologi, dan kandungan metabolit sekunder serbuk instan jamu kunyit asam. Sasambo J Pharm. 2023;4(2):120–31. Https://Doi. Org /10.29303/Sjp.V4i2.257
22. Sari N, Latief M, Elisma E. Uji Aktivitas Ekstrak Etanol Daun Sungkai (Peronema canescens Jack) Terhadap Penyembuhan Luka Bakar Pada Kelinci Jantan (Oryctolagus cuniculus). Indones J Pharma Sci [Internet]. 2022;4(1 SE-):113–22. Available from: https://mail.onlinejournal.unja.ac.id/IJPS/article/view/18201
Downloads
Published
Issue
Section
License
Copyright (c) 2025 Dila Maimunah, Na’imatul Retno F, Octaviana Dyah Oentari (Author)
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
